Systems Biology: Computational and Mathematical Methods

by E. Mjolsness, P. Baldi, and B. Shapiro

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Chapter 2: Biological Dynamics and Reaction Kinetics

Supplementary Material

Electronic Notebooks

  • Mass action kinetics
  • Stochastic simulation algorithm
  • PIP3 metabolism
  • Analytic solution of 2×2 master equation for binding/unbinding
  • Analytic solution of trivalent reaction A+B <–> C

Exercises

  • Hill functions
  • Master equation
  • Trivalent mass action

Figures: sources

  • Hill functions, n=1 and n=2
  • Convergence of bound/unbound probability
  • S-E-P deterministic simulation
  • S-E-P stochastic simulation

Text Outline

  • Example: Growth factor response
  • Elementary dynamical models
  • Mapping biology to mathematics and computation
  • Causal network dynamics
  • Summary

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